We offer a wide selection of stones and materials for your next kitchen renovation project:
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When it comes to kitchen remodeling in Hanahan, SC installing new kitchen cabinets is a great idea. If you're already upgrading or replacing your kitchen countertops, having new cabinets that match the aesthetics of your kitchen makeover is a no-brainer.
At Stone City KB, we believe that everyone deserves an elegant, versatile kitchen with stunning cabinetry. That's why our team will work closely with you to discover the material, texture, and style of cabinets you're craving. Once we do, we handle all the heavy lifting, including cabinet design and installation in your home.
So, why should you install new kitchen cabinets alongside your countertops? Here are just a few reasons:
Many customers install new kitchen cabinets because they're already remodeling their kitchen and need their cabinets to match the aesthetics of their updated space. Do you want your kitchen to feel more open and airier? Do you have specific lifestyle requirements that necessitate a particular cabinet material? Our kitchen cabinet experts can help you find the perfect cabinet setup for your needs.
Having a uniform aesthetic throughout your kitchen and home is important. But from a practical standpoint, new kitchen cabinets often mean more kitchen storage. That's a big deal for families, especially when younger children are involved. If you find that your countertops are magnets for clutter, new cabinetry can help remove the mess and stress less. The more storage your kitchen has, the easier it will be to use your kitchen for cooking and entertaining.
Take a few moments and check out the bones of your current cabinets. Low-quality, cheap cabinets are often a turnoff for potential buyers. If you plan on selling your home in the next few years, one of the best ways to boost resale value is with new cabinetry.
Is it a pain in the side to cook in your kitchen? Whether it's due to clutter, design, or something else, many of our customers want new cabinets so that their kitchen is functional again. New cabinets give you more storage, as mentioned above, but they can also make your kitchen more functional, depending on design and remodeling preferences. If you love to cook for your family and get-togethers, investing in new kitchen cabinets can help you do more of what you love.
Whether you're looking to "wow" a new client or work colleague or just want to make your neighbors a little jealous, upgrading your kitchen cabinets is a great way to do so. Of course, first impressions have always mattered, but particularly so in real estate. When the time comes to sell your home, having custom cabinets and countertops in your kitchen can set you apart from other sellers.
Here at Stone City Kitchen & Bath, we specialize in custom kitchen countertops and cabinets designed especially for you. Whether you've been dreaming of traditional wood cabinets or need sleek, elegant granite countertops, we've got you covered. We are committed to affordable options while holding true to our craftsmanship and skills, providing customers with the best kitchen renovations in South Carolina.
If you're looking for the largest selection and the best prices, visit our showroom or contact us today. You've worked hard to make your home special, so why not your kitchen too? From design to installation, our team is here to help you every step of the way.843-764-3333
FMRP and tumor immunityMany tumors have developed mechanisms rendering them resistant to attack and destruction by the immune system. Zeng et al. report that fragile X mental retardation protein (FMRP) is highly expressed in human cancers, and they propose that it is involved in antitumor immunity. FMRP is best known as an RNA-binding protein that regulates the stability and translation of neuronal RNAs. By genetically inactivating the FMRP gene in mouse cancer cells, the researchers found that FMRP-deficient tumors had reduc...
Many tumors have developed mechanisms rendering them resistant to attack and destruction by the immune system. Zeng et al. report that fragile X mental retardation protein (FMRP) is highly expressed in human cancers, and they propose that it is involved in antitumor immunity. FMRP is best known as an RNA-binding protein that regulates the stability and translation of neuronal RNAs. By genetically inactivating the FMRP gene in mouse cancer cells, the researchers found that FMRP-deficient tumors had reduced growth and were more susceptible to attack by T lymphocytes. Tumor cells lacking FMRP showed remodeling of the tumor microenvironment, macrophage polarization, and upregulation of the chemokines involved in effector CD8+ T cell recruitment. —PNK
Cancer biology and therapy have been transformed by knowledge about immunoregulatory mechanisms that govern adaptive immunity. Although some forms of treatment resistance are related to the intentionally transitory operations of the adaptive immune system, others reflect more subtle requirements to modulate the immune system in different contexts. In this work, we identified an immunoregulatory mechanism involving the neuronal RNA binding protein fragile X mental retardation protein (FMRP), which broadly regulates protein translation and mRNA stability and is aberrantly up-regulated in multiple forms of cancer.
This study was motivated by reports that cancer cells naturally overexpressing FMRP, whose loss of expression in developing neurons causes cognitive defects, were invasive and metastatic. We investigated the expression of FMRP in human tumors, further assessed its tumor-promoting functions in mouse models of cancer, and evaluated its association with prognosis for human cancer patients.
When human tumor tissue microarrays were immunostained for expression of FMRP, a majority of tumors expressed FMRP, whereas cognate normal tissues did not. To investigate the functional significance of this broad up-regulation, the FMR1 gene was ablated through CRISPR-Cas9 gene editing (FMRP-KO, where KO indicates knockout) in mouse cancer cell lines that were inoculated into both immunodeficient and syngeneic immunocompetent mice to establish tumors in parallel with wild-type (WT) FMRP-expressing cell lines. Mice bearing FMRP-KO tumors had similar survival compared with isogenic WT tumors in immunodeficient hosts, indicating that FMRP was not involved in stimulating tumor growth per se. By contrast, tumor growth was impaired and survival extended in immunocompetent hosts, implicating the adaptive immune system. Indeed, FMRP-expressing WT tumors were largely devoid of T cells, whereas FMRP-KO tumors were highly inflamed. Depletion of CD8 and CD4 T cells restored tumor growth and reduced survival, implicating FMRP in immune evasion in WT tumors. WT and FMRP-KO tumors were profiled by single-cell RNA sequencing, revealing marked differences in genome-wide transcription and abundance of cancer cells, macrophages, and T cells. To elucidate the effects of this multifaceted regulatory protein, we performed several functional perturbations, revealing that: FMRP-expressing cancer cells produce the chemokine interleukin-33 (IL-33), which induces regulatory T cells, as well as tumor-secreted protein S (PROS1) ligand and exosomes that elicit tumor-promoting (M2) macrophages. Both cell types are immunosuppressive, collectively contributing to the barrier against T cell attack. By contrast, FMRP-KO cancer cells down-regulate all three factors and up-regulate C-C motif chemokine ligand 7 (CCL7), which helps recruit and activate T cells. Additionally, immunostimulatory macrophages develop in this context that express three proinflammatory chemokines—CCL5, CXCL9, and CXCL10—which cooperate with CCL7 in recruiting T cells. Finally, neither FMR1 mRNA nor FMRP protein levels were sufficient to predict outcomes in cohorts of cancer patients. Recognizing FMRP’s function as an RNA binding protein that modulates mRNA stability and hence levels in transcriptome datasets, a gene signature reflecting FMRP’s cancer regulatory activity (involving 156 genes) was developed by comparing FMRP-expressing versus FMRP-deficient cancer cells, both in culture and within tumors. Our FMRP cancer activity signature was prognostic for survival across multiple human cancers; anticorrelated with the intensity of T cell infiltration in different tumor types, consistent with FMRP’s immunosuppressive effects; and was associated with comparatively poor responses to immune checkpoint inhibitors and immune-dependent chemotherapy in selected cohorts.
FMRP is revealed as a regulator of a network of genes and cells in the tumor microenvironment that contribute to the capability of tumors to evade immune destruction.
Many human cancers manifest the capability to circumvent attack by the adaptive immune system. In this work, we identified a component of immune evasion that involves frequent up-regulation of fragile X mental retardation protein (FMRP) in solid tumors. FMRP represses immune attack, as revealed by cancer cells engineered to lack its expression. FMRP-deficient tumors were infiltrated by activated T cells that impaired tumor growth and enhanced survival in mice. Mechanistically, FMRP’s immunosuppression was multifactorial, involving repression of the chemoattractant C-C motif chemokine ligand 7 (CCL7) concomitant with up-regulation of three immunomodulators—interleukin-33 (IL-33), tumor-secreted protein S (PROS1), and extracellular vesicles. Gene signatures associate FMRP’s cancer network with poor prognosis and response to therapy in cancer patients. Collectively, FMRP is implicated as a regulator that orchestrates a multifaceted barrier to antitumor immune responses.
After being reelected for another term on Tuesday, Hanahan Mayor Christie Rainwater is already preparing for the next four years.HANAHAN, S.C. (WCSC) - After being reelected for another term on Tuesday, Hanahan Mayor Christie Rainwater is already preparing for the next four years.In this year’s election, no opponents ran against Rainwater, which she says was a relief to not sit on the edge of her seat and worry about winning or not.“I feel like the residents of the city have seen the work I’ve put in, a...
After being reelected for another term on Tuesday, Hanahan Mayor Christie Rainwater is already preparing for the next four years.
HANAHAN, S.C. (WCSC) - After being reelected for another term on Tuesday, Hanahan Mayor Christie Rainwater is already preparing for the next four years.
In this year’s election, no opponents ran against Rainwater, which she says was a relief to not sit on the edge of her seat and worry about winning or not.
“I feel like the residents of the city have seen the work I’ve put in, and they want that to keep going,” she says. “They want the momentum to continue, and no one ran against me. I’m able to really continue keeping that momentum going.”
The Hanahan City Council and school board members were all reelected on Tuesday, and the mayor says will continue as a strong partnership because of the established relationships.
Similar to the rest of the Lowcountry, Hanahan continues to grow. Rainwater focused on building economic development and recreation in the area by adding two new parks over the last four years.
“Really bringing this quality of life to the residents is what we’ve been doing over the past four years and will continue to do over the next four,” she says.
As for the upcoming four years, the mayor really wants to focus on flooding concerns, more economic growth and additional housing for the community. She also mentioned that the Lowcountry Rapid Transit plans include four stops that will positively impact Hanahan.
“We are really looking at our specifically downtown area and how can we allow for housing that will work for everyone,” Rainwater says. “We have changed the ordinances over the past few years that will allow for us to build up a little higher and bring that in.”
The mayor also expressed that Hanahan has a small-town feel despite being the seventeenth-largest city in South Carolina.
“I like to say I bleed blue and orange,” she says. “Hanahan is the heart of the Lowcountry. When you look at its location, you’ve got downtown Charleston, Summerville, Mount Pleasant, West Ashley, and right in the heart, you’ll find Hanahan. The truth is, it’s not just because of its location; the people in Hanahan are so special.”
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HANAHAN, S.C. (HOLY CITY SINNER) — Press ReleaseSeamonWhiteside (SW+), a full-service site design firm throughout the Carolinas, is nearing completion of the brand-new Hanahan Recreation Complex.This multi-use recreation project is the first to open since the City of Hanahan’s large population growth over the last several years and is a much-needed addition to the community.The new complex located in Hanahan off of Henry Brown Boulevard and adjacent to Bowen’s Corner Elementary School, will bri...
HANAHAN, S.C. (HOLY CITY SINNER) — Press Release
SeamonWhiteside (SW+), a full-service site design firm throughout the Carolinas, is nearing completion of the brand-new Hanahan Recreation Complex.
This multi-use recreation project is the first to open since the City of Hanahan’s large population growth over the last several years and is a much-needed addition to the community.
The new complex located in Hanahan off of Henry Brown Boulevard and adjacent to Bowen’s Corner Elementary School, will bring great value to the City’s residents and the Berkeley County School District with many added facilities and recreational uses.
SeamonWhiteside is the lead consultant on this $12M+ project and has worked closely with the City of Hanahan since 2016.
The firm provided Programming/Master Planning, Budgeting Assistance, CDs, Permitting, Bid Administration and Procurement, and Construction Administration.
The complex will offer dog parks, walking trails, courts for tennis, volleyball, and basketball, a playground, a multi-purpose recreation building, public parking, restrooms, picnic areas including a covered pavilion, and synthetic and natural sports fields.
“The project is nearing the finish line, and we can’t wait for the City of Hanahan residents to experience what we’ve been working on over the last several years. Located just steps away from Bowen’s Corner Elementary School, this will be a convenient and accessible resource for the community,” says Jennifer Palmer, Director of the SeamonWhiteside Summerville Office. “A fun fact about this project was the property used to be owned by the Federal Government Joint Base Charleston and was part of an old blast zone for testing missiles. All of the natural wetlands remain undisturbed and we utilized a timber bridge, designed by York Bridges, with a very natural park-like aesthetic for the road crossing spanning the wetland to join the two sides of the complex. It is thrilling to see it all come to life and I cannot wait to see it being utilized by the community.”
SeamonWhiteside worked closely on this project with Southeastern Surveying, ECS, Critical Systems Engineering, McSweeney Engineers, and architect Chris Karpus.
The Hanahan Recreation Complex began construction in June 2021 and is now nearing completion, with an expected finish and open date in early 2023.
To learn more about SeamonWhiteside, visit www.seamonwhiteside.com.
A Ludwig Cancer Research study has revealed a single protein expressed at high levels by cancer cells across a broad range of malignancies that erects a multifaceted barrier to anti-cancer immune responses in mouse models of cancer and so shields tumors from immune detection and destruction.Led by Ludwig Lausanne's Douglas Hanahan, two former scientists in his lab Qiqun Zeng and Sadegh Saghafinia, and graduate student Agnieszka Chryplewicz, the study also describes a signature of gene expression induced by the protein, named FMRP, tha...
A Ludwig Cancer Research study has revealed a single protein expressed at high levels by cancer cells across a broad range of malignancies that erects a multifaceted barrier to anti-cancer immune responses in mouse models of cancer and so shields tumors from immune detection and destruction.
Led by Ludwig Lausanne's Douglas Hanahan, two former scientists in his lab Qiqun Zeng and Sadegh Saghafinia, and graduate student Agnieszka Chryplewicz, the study also describes a signature of gene expression induced by the protein, named FMRP, that encompasses 156 distinct genes and predicts poor patient survival across multiple types of cancer. The findings, reported in the journal Science, could with further development inform the selection of patients likely to benefit from immunotherapies and the development of new therapies of this kind for multiple types of cancer.
Our study has detailed a previously unknown and apparently common mechanism by which malignant cells shut down anti-cancer immune responses. We have shown that the hyperexpression of FMRP, which we and others have previously linked to tumor progression, doesn't directly drive cancer cell proliferation and tumor growth. Rather, it supports the ability of malignant cells to manipulate the types and functional states of immune cells around them in a manner that very effectively subverts immune attack."
Douglas Hanahan, distinguished scholar at the Ludwig Institute for Cancer Research Lausanne Branch
A protein primarily expressed in neurons, FMRP has been extensively studied as a factor whose loss of expression during embryogenesis is associated with the neuro-developmental disorder fragile X syndrome, which causes severe intellectual disability. Functionally, FMRP is known to help stabilize the messenger RNA readouts of genes in cells and to regulate translation of that information into proteins. But its role in cancer progression was less clear.
The researchers began by showing that FMRP levels are elevated across multiple types of tumors. To examine its function in cancer, they applied CRISPR-Cas9 gene editing to delete FMR1, the gene that encodes FMRP, in mouse cancer cell lines. They then used the engineered cell lines to generate mouse models of pancreatic, colon, melanoma and breast tumors and compared them to matching tumors that retained their FMR1 genes, using mice that either had or lacked intact immune systems.
While all tumors grew similarly in culture and in immunodeficient mice, the ones that lacked the FMR1 gene were severely impaired in mice with competent immune systems. They were also heavily infiltrated with helper and cytotoxic T cells, which play a central role in anti-cancer immunity. Those with intact FMR1 genes, on the other hand, progressed aggressively and were by comparison so-called "immune deserts"-;devoid of anti-tumor T cells. When T cells were removed from the FMR1-deficient tumors, they resumed growth, suggesting that FMRP supports tumor progression through its effects on the immune response.
The researchers discovered that the gene-expression program regulated by FMRP in cancer cells activates multiple mechanisms of defense that support immune evasion.
Among these is the release of factors that variously promote the induction of regulatory T cells-;which suppress the activity of cytotoxic T cells-;or reprogram immune cells known as the macrophages into a functional state in which they support the growth and survival of cancer cells instead of their destruction, largely by pacifying T cells.
The loss of FMRP in cancer cells, meanwhile, not only reversed their immunosuppressive effects but also induced their secretion of a factor that attracts T cells. Additionally, the FMRP-deficient cancer cells released signals that instructed tumor-infiltrating macrophages to adopt a stimulatory program that helped recruit and activate tumor-killing T cells.
While FMRP expression itself isn't a reliable prognostic biomarker for cancer outcomes, the researchers report that a signature of gene expression reflecting the regulatory network it induces consistently predicts relatively poor odds of survival in multiple types of cancer.
"We are hopeful that these discoveries can be translated into diagnostics and therapies of benefit to cancer patients, as the hallmark capability of cancers to circumvent immune responses underlies the resistance of many tumor types to immunotherapy," said Hanahan. To that point, the researchers have spun off a company named Opna Bio that is developing cancer drugs targeting FMRP and the pathways through which it exerts its effects.
Saghafinia, S., et al. (2022) Aberrant hyperexpression of the RNA binding protein FMRP in tumors mediates immune evasion. Science. doi.org/10.1126/science.abl7207.
Tags: Biomarker, Cancer, Cancer diagnostics, Cas9, Cell, Cell Proliferation, CRISPR, Developmental Disorder, Diagnostics, Disability, Drugs, Embryogenesis, Fragile X Syndrome, Gene, Gene Expression, Genes, Immune Response, immunity, Immunotherapy, Malignant, Melanoma, Neurons, Proliferation, Protein, Research, RNA, Syndrome, Translation, Tumor
CHARLESTON, S.C. (WCSC) - Week 9 kicks off with one game on Thursday and the rest of the schedule on Friday. Check back here for scores, highlights and more!10/20Beaufort 48, North Charleston 8 - The Cougars fall to 3-7 (0-4)Philip Simmons 22, Hanahan 0 - The Iron Horses Michael Spignardo blocked 2 punts including one that went for a touchdown as Philip Simmons improved to 6-3 (2-1) while the Hawks fall to 6-2 (2-1)Ft. Dorchester 51, West Ashley 7 - The Patriots move to 6-3 (3-0) with t...
CHARLESTON, S.C. (WCSC) - Week 9 kicks off with one game on Thursday and the rest of the schedule on Friday. Check back here for scores, highlights and more!
Beaufort 48, North Charleston 8 - The Cougars fall to 3-7 (0-4)
Philip Simmons 22, Hanahan 0 - The Iron Horses Michael Spignardo blocked 2 punts including one that went for a touchdown as Philip Simmons improved to 6-3 (2-1) while the Hawks fall to 6-2 (2-1)
Ft. Dorchester 51, West Ashley 7 - The Patriots move to 6-3 (3-0) with the win while the Wildcats drop to 7-3 (1-3)
Ashley Ridge 13, Summerville 28 - The Green Wave go to 8-1 (3-0) while the Swamp Foxes drop to 6-3 (1-2). Summerville will host Ft. Dorchester next Friday with the Region title on the line.
Wando 34, Goose Creek 53 - The Gators clinch the Region championship with the win and improve to 3-6 (3-0). Wando drops to 2-7 (1-3).
Stratford 7, Berkeley 12 - The Stags break their losing streak and go to 2-7 (1-2). The Knights fall to 2-6 (1-2).
Stall 18, Cane Bay 65 - The Cobras improve to 6-2 (3-1) while the Warriors remain winless at 0-8 (0-4).
Colleton County 21, Beckham 31 - The Bengals go to 7-2 (3-1) while the Cougars drop 1-8 (0-4).
James Island 45, Hilton Head 8 - The Trojans move to 8-1 (4-0) and will face Beckham next Friday for the region title.
Bishop England 0, Oceanside Collegiate 36 - The Landsharks improve to 7-1 (3-0) while the Bishops fall to 1-8 (0-3).
Lake Marion 27, Academic Magnet 7 - The Raptors fall to 5-3 (0-3).
Woodland 28, Barnwell 34 - The Wolverines suffer their first loss of the season and fall to 8-1 (2-1).
Cross 54, Baptist Hill 0 - The Trojans clinch a Region championship with the win and improve to 7-2 (3-0). The Bobcats fall to 5-2 (2-1).
St. John’s 19, Military Magnet 6 - The Islanders go to 2-6 (2-1) while the Eagles fall to 2-8 (1-3)
Cardinal Newman 24, Porter-Gaud 28 - The Cyclones improve to 4-4 with the victory
Florence Christian 26, First Baptist 27 - The Hurricanes move to 4-4 on the year
Pinewood Prep 40, Thomas Heyward 20 - The Panthers go to 4-5
Pee Dee Academy 34, Northwood Academy 0 - The Chargers fall to 0-9
St. John’s Christian 46, Dorchester Academy 20 - The Cavaliers improve to 5-3 while the Raiders drop to 5-4
Colleton Prep 19, Beaufort Academy 20 - The War Hawks suffer their first loss of the season and fall to 7-1
Northside Christian 32, Palmetto Christian 8 - The Eagles fall to 0-8
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